Well, in Link's Awakening DX you end up being unable to get the vast majority of the camera shop pictures if you don't do certain things with Marin (and I've seen all the innuendos from a mile off, so don't even bother) while she's trailing you to Animal Village.You see, by being unable to fuse with people at a certain point in the game, the prizes they would've given me are now inaccessable. Since when has inaccessability been ANY kind of feature in any previous Zelda game?
I got, like, none of those pictures, and I don't really relish the thought of having to start a new play file just to see them. Still, I wouldn't say that this ruined the game for me.